Clinical, Cosmetic and Investigational Dermatology (Feb 2023)
Primary Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Literature Review
Abstract
Sadan Mohammed Al Harbi,1 Nada Jomaan Al Ghamdi,1 Tarek Mohamed Elsharkawy,2 Mohammad Abdelqader Al Hamad,2 Sultan Bajawi1 1Department of Dermatology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia; 2Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi ArabiaCorrespondence: Sadan Mohammed Al Harbi, Department of Dermatology, College of Medicine, Imam Abdulrahman Bin Faisal University, Post Box No. 1982, Dammam, 31441, Saudi Arabia, Email [email protected]: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a lymphoproliferative disorder in which the majority of cells are reactive T cells with only a minor population of neoplastic large B cells. THRLBCL is a very rare lymphoma, and most cases are nodal THRLBCL; an extranodal case of THRLBCL presenting primarily on the skin is an extremely rare occurrence with only a few cases reported in the literature. Here, we report a case of a primary cutaneous THRLBCL in a 41-year-old Saudi male who presented unusually with multiple skin lesions. He was successfully treated with electron beam radiotherapy and had a complete resolution with no recurrence as of his 24-month follow-up.Keywords: T-cell-rich B-cell lymphoma, lymphoproliferative disorder, radiotherapy, neoplastic B cells
