Nature Communications (Feb 2022)
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo
- Maki Uenaka,
- Erika Yamashita,
- Junichi Kikuta,
- Akito Morimoto,
- Tomoka Ao,
- Hiroki Mizuno,
- Masayuki Furuya,
- Tetsuo Hasegawa,
- Hiroyuki Tsukazaki,
- Takao Sudo,
- Keizo Nishikawa,
- Daisuke Okuzaki,
- Daisuke Motooka,
- Nobuyoshi Kosaka,
- Fuminori Sugihara,
- Thomas Boettger,
- Thomas Braun,
- Takahiro Ochiya,
- Masaru Ishii
Affiliations
- Maki Uenaka
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Erika Yamashita
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Junichi Kikuta
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Akito Morimoto
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Tomoka Ao
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Hiroki Mizuno
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Masayuki Furuya
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Tetsuo Hasegawa
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Hiroyuki Tsukazaki
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Takao Sudo
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Keizo Nishikawa
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- Daisuke Okuzaki
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Daisuke Motooka
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Nobuyoshi Kosaka
- Division of Molecular and Cellular Medicine, Tokyo Medical University
- Fuminori Sugihara
- Core Instrumentation Facility, Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University
- Thomas Boettger
- Max-Plank-Institute for Heart and Lung Research
- Thomas Braun
- Max-Plank-Institute for Heart and Lung Research
- Takahiro Ochiya
- Division of Molecular and Cellular Medicine, Tokyo Medical University
- Masaru Ishii
- Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University
- DOI
- https://doi.org/10.1038/s41467-022-28673-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Bone remodeling involves a switch between bone formation and resorption, but the mechanisms is unclear. Here, the authors show that intercellular communication via extracellular vesicles secreted by mature osteoblasts is a key factor for the switching, via a microRNA-mediated mechanism.
