Менопаузальная гормональная терапия: новый взгляд на старые проблемы

Abstract

The most effective symptomatic treatment of menopause is menopausal hormone therapy (MHT). It has been shown that MHT administered in proper time can not only reduce the frequency and intensity of vasomotor disorders, but also significantly reduce the risk of osteoporosis and coronary heart disease (CHD). However, several research showed the increased risk of venous thromboembolism, stroke and breast cancer in patients receiving MHT, thereby MHT safety was questioned. Despite the fact that the beneficial properties of MHT significantly exceed the possible risks of side effects, modern international guidelines recommend to use minimal doses of MHT. Low-dose and ultra-low dose MHT regimens make it possible to maintain effectiveness, but at the same time reduce the incidence of undesirable side reactions to a minimum.

Keywords

• menopause
• menopausal hormone therapy
• didrogesterone
• estradiol