Viruses (Oct 2021)
Clusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccines
- William M. de Souza,
- Stéfanie P. Muraro,
- Gabriela F. Souza,
- Mariene R. Amorim,
- Renata Sesti-Costa,
- Luciana S. Mofatto,
- Julia Forato,
- Priscilla P. Barbosa,
- Daniel A. Toledo-Teixeira,
- Karina Bispo-dos-Santos,
- Pierina L. Parise,
- Natalia S. Brunetti,
- Joselia C. O. Moreira,
- Vitor A. Costa,
- Daniela M. Cardozo,
- Maria L. Moretti,
- Silvia Barros-Mazon,
- Gabriela F. Marchesi,
- Christiane Ambrosio,
- Fernando R. Spilki,
- Valeria C. Almeida,
- Andre S. Vieira,
- Lair Zambon,
- Alessandro S. Farias,
- Marcelo Addas-Carvalho,
- Bruno D. Benites,
- Rafael E. Marques,
- Ester C. Sabino,
- Andrea B. Von Zuben,
- Scott C. Weaver,
- Nuno R. Faria,
- Fabiana Granja,
- Rodrigo N. Angerami,
- José Luiz Proença-Módena
Affiliations
- William M. de Souza
- Virology Research Centre, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil
- Stéfanie P. Muraro
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Gabriela F. Souza
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Mariene R. Amorim
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Renata Sesti-Costa
- Brazilian Biosciences National Laboratory, Brazilian Centre for Research in Energy and Materials, Campinas 13083-100, Brazil
- Luciana S. Mofatto
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Julia Forato
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Priscilla P. Barbosa
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Daniel A. Toledo-Teixeira
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Karina Bispo-dos-Santos
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Pierina L. Parise
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Natalia S. Brunetti
- Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Joselia C. O. Moreira
- Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Vitor A. Costa
- Hematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, Brazil
- Daniela M. Cardozo
- Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas 13083-862, Brazil
- Maria L. Moretti
- Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, Brazil
- Silvia Barros-Mazon
- Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas 13083-862, Brazil
- Gabriela F. Marchesi
- Campinas Department of Public Health Surveillance, Campinas 13015-904, Brazil
- Christiane Ambrosio
- Campinas Department of Public Health Surveillance, Campinas 13015-904, Brazil
- Fernando R. Spilki
- One Health Laboratory, Feevale University, Novo Hamburgo 93510-235, Brazil
- Valeria C. Almeida
- Campinas Department of Public Health Surveillance, Campinas 13015-904, Brazil
- Andre S. Vieira
- Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Lair Zambon
- Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, Brazil
- Alessandro S. Farias
- Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Marcelo Addas-Carvalho
- Hematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, Brazil
- Bruno D. Benites
- Hematology and Hemotherapy Center, University of Campinas, Campinas 13083-862, Brazil
- Rafael E. Marques
- Brazilian Biosciences National Laboratory, Brazilian Centre for Research in Energy and Materials, Campinas 13083-100, Brazil
- Ester C. Sabino
- Tropical Medicine Institute, Medical School, University of São Paulo, São Paulo 05403-907, Brazil
- Andrea B. Von Zuben
- Campinas Department of Public Health Surveillance, Campinas 13015-904, Brazil
- Scott C. Weaver
- Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
- Nuno R. Faria
- Department of Infectious and Parasitic Disease, Medical School, University of São Paulo, São Paulo 05403-000, Brazil
- Fabiana Granja
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- Rodrigo N. Angerami
- Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas 13083-862, Brazil
- José Luiz Proença-Módena
- Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas 13083-862, Brazil
- DOI
- https://doi.org/10.3390/v13112127
- Journal volume & issue
-
Vol. 13,
no. 11
p. 2127
Abstract
A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, n = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, n = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had ~1.8–3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly.
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