IMPACT OF BONE MARROW-DERIVED MULTIPOTENT MESENCHYMAL STROMAL CELLS ON SPEED OF POLYCAPROLACTONE AND POLYHYDROXYALKANOATE SCAFFOLDS BIODEGRADATION

L. V. Antonova; A. Y. Burago; V. G. Matveyeva; Y. A. Kudryavtseva; M. V. Nasonova; Y. G. Toropova; E. A. Velikanova; A. S. Golovkin

Acta Biomedica Scientifica (May 2012)

IMPACT OF BONE MARROW-DERIVED MULTIPOTENT MESENCHYMAL STROMAL CELLS ON SPEED OF POLYCAPROLACTONE AND POLYHYDROXYALKANOATE SCAFFOLDS BIODEGRADATION

L. V. Antonova,
A. Y. Burago,
V. G. Matveyeva,
Y. A. Kudryavtseva,
M. V. Nasonova,
Y. G. Toropova,
E. A. Velikanova,
A. S. Golovkin

Affiliations

L. V. Antonova: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
A. Y. Burago: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
V. G. Matveyeva: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Y. A. Kudryavtseva: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
M. V. Nasonova: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
Y. G. Toropova: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
E. A. Velikanova: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS
A. S. Golovkin: Institution Research Institute for Complex Issues of Cardiovascular Diseases SB RAMS

Journal volume & issue: Vol. 0, no. 3(2)
pp. 249 – 252

Abstract

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The impact of bone marrow-derived multipotent mesenchymal stromal cells of a bone brain (MSCs BB) on the speed of polycaprolactone and polyhydroxyalkanoate scaffolds biodegradation was studied. The presence of cells on the scaffolds surface was found to catalyze their resorption. 2 months after MSCs-covered scaffolds had. been subcutaneously implanted in rats they degraded completely while scaffolds, which had no MSCs cover, had partially resorbed by that time. The obtained results make necessary further studying of MSCs impact mechanisms on biopolymers resorption speed.

Published in Acta Biomedica Scientifica

ISSN: 2541-9420 (Print); 2587-9596 (Online)
Publisher: Scientific Сentre for Family Health and Human Reproduction Problems
Country of publisher: Russian Federation
LCC subjects: Science
Website: http://actabiomedica.ru/en/

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Abstract

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