Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics

Luís Botelho Carvalho; José Luis Capelo; Carlos Lodeiro; Rajiv Dhir; Luis Campos Pinheiro; Hugo López-Fernández; Gonçalo Martins; Mariana Medeiros; Fernando Díaz; Hugo Miguel Santos

doi:10.1038/s43856-023-00238-4

Communications Medicine (Jan 2023)

Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics

Luís Botelho Carvalho,
José Luis Capelo,
Carlos Lodeiro,
Rajiv Dhir,
Luis Campos Pinheiro,
Hugo López-Fernández,
Gonçalo Martins,
Mariana Medeiros,
Fernando Díaz,
Hugo Miguel Santos

Affiliations

Luís Botelho Carvalho: BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa
José Luis Capelo: BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa
Carlos Lodeiro: BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa
Rajiv Dhir: Department of Pathology, University of Pittsburgh Medical Center
Luis Campos Pinheiro: Urology Department, Central Lisbon Hospital Center
Hugo López-Fernández: CINBIO, Universidade de Vigo, Department of Computer Science, ESEI-Escuela Superior de Ingenierı́a Informática
Gonçalo Martins: BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa
Mariana Medeiros: Urology Department, Central Lisbon Hospital Center
Fernando Díaz: Department of Computer Science, Universidad de Valladolid, Escuela de Ingeniería Informática
Hugo Miguel Santos: BIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa

DOI: https://doi.org/10.1038/s43856-023-00238-4
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 10

Abstract

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Carvalho et al. develop an analysis pipeline for label-free urine proteomics data. Their approach allows monitoring of the disease course in patients with bladder cancer and flags the need for medical intervention.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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