Emerging Microbes and Infections (Dec 2024)
Peripheral nerve injury associated with JEV infection in high endemic regions, 2016–2020: a multicenter retrospective study in China
- Guowei Wang,
- Lianmei Zhong,
- Manxia Wang,
- Juan Zhou,
- Shuting Liu,
- Wang Miao,
- Leilei Li,
- Yonghong Liu,
- Shougang Guo,
- Haining Li,
- Xiaoming Wang,
- Liuqing Xie,
- Min Xie,
- Shihong Fu,
- Tingting Xuan,
- Fan Li,
- Tingting Yang,
- Lufei Shao,
- Mingfang Shi,
- Xiaocong Li,
- Xiaoling Li,
- Li Gao,
- Shaopeng Zhai,
- Jia Ding,
- Tianhong Wang,
- Dayong Liu,
- Guosheng Ma,
- Jiang Wu,
- Dongjun Wan,
- Junlin Guo,
- Xinbo Zhang,
- Jinxia Wu,
- Yinxu Wang,
- Ansong Jin,
- Lei Ma,
- Huan Yang,
- Xuexian He,
- Xiaona Ma,
- Huijuan Liu,
- Boya Ma,
- Ningai Yang,
- Xiaolin Hou,
- Ting Xu,
- Cheng-feng Qin,
- Huanyu Wang,
- Peng Xie,
- Zhenhai Wang
Affiliations
- Guowei Wang
- The First Clinical Medical School, Ningxia Medical University, Yinchuan, People’s Republic of China
- Lianmei Zhong
- Xuanwu Hospital Capital Medical University, Beijing, People’s Republic of China
- Manxia Wang
- Department of Neurology, Lanzhou University Second Hospital, Lanzhou, People’s Republic of China
- Juan Zhou
- Guangzhou Women and Children’s Medical Center, Guangzhou, People’s Republic of China
- Shuting Liu
- Ningxia Medical University, Yinchuan, People’s Republic of China
- Wang Miao
- Neuro-Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
- Leilei Li
- West China Hospital of Sichuan University, Chengdu, People’s Republic of China
- Yonghong Liu
- Department of Neurology, Xijing Hospital, The Air Force Medical University, Xi’an, People’s Republic of China
- Shougang Guo
- Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China
- Haining Li
- Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Xiaoming Wang
- The Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China
- Liuqing Xie
- Meishan People’s Hospital, Meishan, People’s Republic of China
- Min Xie
- Chengdu Seventh People’s Hospital, Chengdu, People’s Republic of China
- Shihong Fu
- National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
- Tingting Xuan
- The First Clinical Medical School, Ningxia Medical University, Yinchuan, People’s Republic of China
- Fan Li
- National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
- Tingting Yang
- Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Lufei Shao
- Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Mingfang Shi
- Department of Pediatrics, Yibin Hospital, Children's Hospital of Chongqing Medical University, Yibin, People’s Republic of China
- Xiaocong Li
- The First Clinical Medical School, Ningxia Medical University, Yinchuan, People’s Republic of China
- Xiaoling Li
- Department of Neurology, Lanzhou University Second Hospital, Lanzhou, People’s Republic of China
- Li Gao
- Baoji Central Hospital, Baoji, People’s Republic of China
- Shaopeng Zhai
- Department of Neurology, Lanzhou University Second Hospital, Lanzhou, People’s Republic of China
- Jia Ding
- The First People’s Hospital of Tianshui, Tianshui, People’s Republic of China
- Tianhong Wang
- The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China
- Dayong Liu
- The Affiliated Hospital of Gansu Medical College, Pingliang, People’s Republic of China
- Guosheng Ma
- Gansu Provincial People’s Hospital, Lanzhou, People’s Republic of China
- Jiang Wu
- The First People’s Hospital of Longnan, Longnan, People’s Republic of China
- Dongjun Wan
- The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, Lanzhou, People’s Republic of China
- Junlin Guo
- Qingyang People's Hospital, Qingyang, People’s Republic of China
- Xinbo Zhang
- Department of Neurology, Xijing Hospital, The Air Force Medical University, Xi’an, People’s Republic of China
- Jinxia Wu
- Department of Pediatrics, Yibin Hospital, Children's Hospital of Chongqing Medical University, Yibin, People’s Republic of China
- Yinxu Wang
- The Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China
- Ansong Jin
- The First Affiliated Hospital of Kunming Medical University, Kunming, People’s Republic of China
- Lei Ma
- Emergency Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Huan Yang
- Emergency Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Xuexian He
- Cerebrospinal Fluid Laboratory, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Xiaona Ma
- Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Huijuan Liu
- Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Boya Ma
- Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Ningai Yang
- Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Xiaolin Hou
- Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Ting Xu
- General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- Cheng-feng Qin
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People’s Republic of China
- Huanyu Wang
- National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China
- Peng Xie
- NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, Chongqing, People’s Republic of China
- Zhenhai Wang
- Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China
- DOI
- https://doi.org/10.1080/22221751.2024.2337677
- Journal volume & issue
-
Vol. 13,
no. 1
Abstract
ABSTRACTPreviously, we reported a cohort of Japanese encephalitis (JE) patients with Guillain–Barré syndrome. However, the evidence linking Japanese encephalitis virus (JEV) infection and peripheral nerve injury (PNI) remains limited, especially the epidemiology, clinical presentation, diagnosis, treatment, and outcome significantly differ from traditional JE. We performed a retrospective and multicenter study of 1626 patients with JE recorded in the surveillance system of the Chinese Center for Disease Control and Prevention, spanning the years 2016–2020. Cases were classified into type 1 and type 2 JE based on whether the JE was combined with PNI or not. A comparative analysis was conducted on demographic characteristics, clinical manifestations, imaging findings, electromyography data, laboratory results, and treatment outcomes. Among 1626 laboratory confirmed JE patients, 230 (14%) were type 2 mainly located along the Yellow River in northwest China. In addition to fever, headache, and disturbance of consciousness, type 2 patients experienced acute flaccid paralysis of the limbs, as well as severe respiratory muscle paralysis. These patients presented a greater mean length of stay in hospital (children, 22 years [range, 1–34]; adults, 25 years [range, 0–183]) and intensive care unit (children, 16 years [range, 1–30]; adults, 17 years [range, 0–102]). The mortality rate was higher in type 2 patients (36/230 [16%]) compared to type 1 (67/1396 [5%]). The clinical classification of the diagnosis of JE may play a crucial role in developing a rational treatment strategy, thereby mitigating the severity of the disease and potentially reducing disability and mortality rates among patients.
Keywords
- Japanese encephalitis virus
- peripheral nerve injury
- clinical classification
- endemic
- electromyography
