A laboratory Study On The Effect Of Temperature And pH On The Stability Of Tilmicosin

Abstract

The effect of temperature and pH on the stability of the antibacterial “tilmicosin” was evaluated in this study. The temperature degrees studied were 25 , 45 and 65 oC each for 24 hours , while the pH values studied were 6 , 7 and 8 each at room temperature and for 24 hours also. A microbiological assay method was employed for analysis of the collected samples. The results of analysis indicate significant drop in activity of the drug as a results of exposure to temperature or pH. The above mentioned results necessitate the maintenance of drinking water in the storage depots of the field below 65 oC especially in summer season, so to keep the chemical structure of the drug and to offer enough therapeutic concentration to reach the tissue.