α-Lipoic acid as the main pharmacological drug for in- and outpatient treatment of diabetic polyneuropathy

Abstract

α-Lipoic acid (thioctic) (ALA) is the most applicable pharmacological drug for treatment of diabetic polyneuropathy. The articles explores the results of experimental studies on α-Lipoic acid effect upon formation mechanisms of peripheral nerves affection under hyperglycemia and also the data of numerous randomized controlled trials and meta-analyses on studying ALA efficiency under symptomatic diabetic polyneuropathy. It was proved that amelioration of patients with diabetic polyneuropathy is observed both while using ALA infusions and tableted form of the drug. The authors conclude that α-lipoic acid is a drug for treatment of pathogenetic development mechanisms of diabetic polyneuropathy with the most demonstrated efficiency.

Keywords

• diabetic polyneuropathy
• pathogenesis of the diabetic polyneuropathy
• pathogenetic therapy of diabetic polyneuropathy
• alpha-lipoic acid
• berlition
• pain syndrome in diabetic polyneuropathy