Identification of host–pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank

Alexander J. Mentzer; Nicole Brenner; Naomi Allen; Thomas J. Littlejohns; Amanda Y. Chong; Adrian Cortes; Rachael Almond; Michael Hill; Simon Sheard; Gil McVean; UKB Infection Advisory Board; Rory Collins; Adrian V. S. Hill; Tim Waterboer

doi:10.1038/s41467-022-29307-3

Nature Communications (Apr 2022)

Identification of host–pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank

Alexander J. Mentzer,
Nicole Brenner,
Naomi Allen,
Thomas J. Littlejohns,
Amanda Y. Chong,
Adrian Cortes,
Rachael Almond,
Michael Hill,
Simon Sheard,
Gil McVean,
UKB Infection Advisory Board,
Rory Collins,
Adrian V. S. Hill,
Tim Waterboer

Affiliations

Alexander J. Mentzer: The Wellcome Centre for Human Genetics, University of Oxford
Nicole Brenner: Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
Naomi Allen: Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
Thomas J. Littlejohns: Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
Amanda Y. Chong: The Wellcome Centre for Human Genetics, University of Oxford
Adrian Cortes: Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
Rachael Almond: UK Biobank
Michael Hill: Nuffield Department of Population Health, University of Oxford
Simon Sheard: UK Biobank
Gil McVean: Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford
UKB Infection Advisory Board
Rory Collins: UK Biobank
Adrian V. S. Hill: The Wellcome Centre for Human Genetics, University of Oxford
Tim Waterboer: Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)

DOI: https://doi.org/10.1038/s41467-022-29307-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Here, the authors design a multiplex serology platform to quantitatively measure antibodies against 20 infectious agents in UK Biobank participants and confirm associations of antibody responses with sociodemographic characteristics, HLA genetic variants, and disease outcomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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