PLoS ONE (Jan 2012)

Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.

  • Juan Shi,
  • Yifei Zhang,
  • Weiqiong Gu,
  • Bin Cui,
  • Min Xu,
  • Qun Yan,
  • Weiqing Wang,
  • Guang Ning,
  • Jie Hong

DOI
https://doi.org/10.1371/journal.pone.0048777
Journal volume & issue
Vol. 7, no. 11
p. e48777

Abstract

Read online

BackgroundLiver fatty acid-binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old.Methodology and principal findingsCross-sectional analysis including 200 obese and 172 normal-weight subjects matched for age and sex, anthropometric measurements were performed and serum FABP1 and biochemical characteristics were measured. Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR) and by the insulin sensitivity index (S(i)) derived from Bergman's minimal model. FABP1 levels in obese subjects were significantly higher than those in normal-weight subjects (pConclusions and significanceSerum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults. Our data supports the fact that FABP1 might be an important mediator participating in fatty acid metabolism and energy balance.