Nature Communications (Nov 2017)

Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold

  • Wen-Bo Shen,
  • Qing Sun,
  • Long Li,
  • Xin Liu,
  • Bo Zhou,
  • Juan-Zhu Yan,
  • Xin Lu,
  • Long-Wu Ye

DOI
https://doi.org/10.1038/s41467-017-01853-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Fused N-heterocycles are structural motifs observed in natural products and bioactive compounds. Here, the authors developed divergent copper- and gold-catalyzed oxidative cyclizations of diynes to two types of tricyclic N-heterocycles and rationalized the product selectivity by theoretical calculations.