Nature Communications (Nov 2017)
Divergent synthesis of N-heterocycles via controllable cyclization of azido-diynes catalyzed by copper and gold
Abstract
Fused N-heterocycles are structural motifs observed in natural products and bioactive compounds. Here, the authors developed divergent copper- and gold-catalyzed oxidative cyclizations of diynes to two types of tricyclic N-heterocycles and rationalized the product selectivity by theoretical calculations.