Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Franziska Hildebrandt; Alma Andersson; Sami Saarenpää; Ludvig Larsson; Noémi Van Hul; Sachie Kanatani; Jan Masek; Ewa Ellis; Antonio Barragan; Annelie Mollbrink; Emma R. Andersson; Joakim Lundeberg; Johan Ankarklev

doi:10.1038/s41467-021-27354-w

Nature Communications (Dec 2021)

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Franziska Hildebrandt,
Alma Andersson,
Sami Saarenpää,
Ludvig Larsson,
Noémi Van Hul,
Sachie Kanatani,
Jan Masek,
Ewa Ellis,
Antonio Barragan,
Annelie Mollbrink,
Emma R. Andersson,
Joakim Lundeberg,
Johan Ankarklev

Affiliations

Franziska Hildebrandt: Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University
Alma Andersson: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Sami Saarenpää: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Ludvig Larsson: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Noémi Van Hul: Department of Cell and Molecular Biology, Karolinska Institutet Stockholm
Sachie Kanatani: Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University
Jan Masek: Department of Cell and Molecular Biology, Karolinska Institutet Stockholm
Ewa Ellis: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet
Antonio Barragan: Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University
Annelie Mollbrink: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Emma R. Andersson: Department of Cell and Molecular Biology, Karolinska Institutet Stockholm
Joakim Lundeberg: Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
Johan Ankarklev: Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University

DOI: https://doi.org/10.1038/s41467-021-27354-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previously uncharacterized structures within liver tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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