Recurrent network dynamics shape direction selectivity in primary auditory cortex

Destinee A. Aponte; Gregory Handy; Amber M. Kline; Hiroaki Tsukano; Brent Doiron; Hiroyuki K. Kato

doi:10.1038/s41467-020-20590-6

Nature Communications (Jan 2021)

Recurrent network dynamics shape direction selectivity in primary auditory cortex

Destinee A. Aponte,
Gregory Handy,
Amber M. Kline,
Hiroaki Tsukano,
Brent Doiron,
Hiroyuki K. Kato

Affiliations

Destinee A. Aponte: Department of Psychiatry, University of North Carolina at Chapel Hill
Gregory Handy: Departments of Neurobiology and Statistics, University of Chicago
Amber M. Kline: Department of Psychiatry, University of North Carolina at Chapel Hill
Hiroaki Tsukano: Department of Psychiatry, University of North Carolina at Chapel Hill
Brent Doiron: Departments of Neurobiology and Statistics, University of Chicago
Hiroyuki K. Kato: Department of Psychiatry, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/s41467-020-20590-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Aponte et al. show that cortical direction selectivity to frequency modulated sounds is shaped by asymmetric signal amplification within recurrent circuits. Optogenetics and network modelling demonstrate that this asymmetry arises due to broad spatial topography of SOM cell mediated inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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