Studies on the rheology and oxygen mass transfer in the clavulanic acid production by Streptomyces clavuligerus

Brazilian Journal of Chemical Engineering. 2000;17(4-7):827-834 DOI 10.1590/S0104-66322000000400045


Journal Homepage

Journal Title: Brazilian Journal of Chemical Engineering

ISSN: 0104-6632 (Print); 1678-4383 (Online)

Publisher: Brazilian Society of Chemical Engineering

LCC Subject Category: Technology: Chemical technology: Chemical engineering

Country of publisher: Brazil

Language of fulltext: English

Full-text formats available: PDF, HTML, XML



E. R. Gouveia
A. Baptista-Neto
C.O. Hokka
A.C. Badino Jr.


Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks


Abstract | Full Text

In the present work rheological characteristics and volumetric oxygen transfer coefficient (kLa) were investigated during batch cultivations of Streptomyces clavuligerus NRRL 3585 for production of clavulanic acid. The experimental rheological data could be adequately described in terms of the power law model and logistic equation. Significant changes in the rheological parameters consistency index (K) and flow behavior index (n) were observed with the fermentation evolution. Interesting correlations between the consistency index (K)/biomass concentration (C X) and the flow behavior index (n)/biomass concentration were proposed. Volumetric oxygen mass transfer coefficient (kLa) was determined by the gas balance method. Classical correlation relating the volumetric oxygen mass transfer coefficient to the operating conditions, physical and to transport properties, including apparent viscosity (muap), could be applied to the experimental results.