Case of Extensively Drug-Resistant Shigella sonnei Infection, United States

Abstract

We report extensively drug-resistant (XDR) Shigella sonnei infection in an immunocompromised patient in Texas, USA. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry failed to identify XDR Shigella, but whole-genome sequencing accurately characterized the strain. First-line antimicrobials are not effective against emerging XDR Shigella. Fosfomycin, carbapenems, and tigecycline are potential alternatives.

Keywords

• extensively drug-resistant Shigella
• XDR Shigella
• Shigella sonnei
• antimicrobial resistance
• bacteria
• whole-genome sequencing