Grapevine Shoot Extract Rich in <i>Trans</i>-Resveratrol and <i>Trans</i>-ε-Viniferin: Evaluation of Their Potential Use for Cardiac Health
María del Mar Contreras,
Anouar Feriani,
Irene Gómez-Cruz,
Najla Hfaiedh,
Abdel Halim Harrath,
Inmaculada Romero,
Eulogio Castro,
Nizar Tlili
Affiliations
María del Mar Contreras
Department of Chemical, Environmental and Materials Engineering, Campus Las Lagunillas, Universidad de Jaén, 23071 Jaén, Spain
Anouar Feriani
Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa 2112, Tunisia
Irene Gómez-Cruz
Department of Chemical, Environmental and Materials Engineering, Campus Las Lagunillas, Universidad de Jaén, 23071 Jaén, Spain
Najla Hfaiedh
Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa 2112, Tunisia
Abdel Halim Harrath
Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Inmaculada Romero
Department of Chemical, Environmental and Materials Engineering, Campus Las Lagunillas, Universidad de Jaén, 23071 Jaén, Spain
Eulogio Castro
Department of Chemical, Environmental and Materials Engineering, Campus Las Lagunillas, Universidad de Jaén, 23071 Jaén, Spain
Nizar Tlili
Institut Supérieur des Sciences et Technologies de l’Environnement, Université de Carthage, Hammam Chat 2050, Tunis 1073, Tunisia
A grapevine shoot extract (GSE) was obtained using ultrasound-assisted extraction and characterized. The main phenolic constituents were identified as stilbenoids. Among them, trans-resveratrol and trans-ε-viniferin stood out. The GSE was administered to an isoproterenol-induced myocardial injury animal model. The extract alleviated the associated symptoms of the administration of the drug, i.e., the plasma lipid profile was improved, while the disturbed plasma ion concentration, the cardiac dysfunction markers, the DNA laddering, and the necrosis of myocardial tissue were diminished. This effect could be related to the anti-oxidative potential of GSE associated with its antioxidant properties, the increased levels of endogenous antioxidants (glutathione and enzymatic antioxidants), and the diminished lipid peroxidative markers in the heart. The results also revealed angiotensin-converting enzyme (ACE)-inhibitory activity, which indicated the potential of GSE to deal with cardiovascular disease events. This work suggests that not only trans-resveratrol has a protective role in heart function but also GSE containing this biomolecule and derivatives. Therefore, GSE has the potential to be utilized in the creation of innovative functional ingredients.
