mBio
(Jun 2021)
The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place
Oriana Villafraz,
Hélène Baudouin,
Muriel Mazet,
Hanna Kulyk,
Jean-William Dupuy,
Erika Pineda,
Cyrille Botté,
Daniel Ken Inaoka,
Jean-Charles Portais,
Frédéric Bringaud
Affiliations
Oriana Villafraz
Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France
Hélène Baudouin
Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France
Muriel Mazet
Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France
Hanna Kulyk
Toulouse Biotechnology Institute (TBI), INSA de Toulouse INSA/CNRS 5504, UMR INSA/INRA, Toulouse, France
Jean-William Dupuy
Université de Bordeaux Plateforme Protéome, Bordeaux, France
Erika Pineda
Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France
Cyrille Botté
ORCiD Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, La Tronche, France
Daniel Ken Inaoka
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Jean-Charles Portais
Toulouse Biotechnology Institute (TBI), INSA de Toulouse INSA/CNRS 5504, UMR INSA/INRA, Toulouse, France
Frédéric Bringaud
ORCiD Université de Bordeaux CNRS, Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234, Bordeaux, France
DOI
https://doi.org/10.1128/mBio.00375-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Unusual compartmentalization of metabolic pathways within organelles is one of the most enigmatic features of trypanosomatids. These unicellular eukaryotes are the only organisms that sequestered glycolysis inside peroxisomes (glycosomes), although the selective advantage of this compartmentalization is still not clear.
WeChat QR code
Close
