Chiral acid-catalysed enantioselective C−H functionalization of toluene and its derivatives driven by visible light

Abstract

Asymmetric transformations involving abundant chemical feedstocks such as toluene and its derivatives are rather rare. Here, the authors report the radical enantioselective C(sp3) −C(sp3) coupling of activated ketones with toluenes by means of chiral acid catalysis to afford enantioenriched tertiary alcohols.