PLoS ONE (Jan 2020)

The age-specific burden and household and school-based predictors of child and adolescent tuberculosis infection in rural Uganda.

  • Carina Marquez,
  • Mucunguzi Atukunda,
  • Laura B Balzer,
  • Gabriel Chamie,
  • Joel Kironde,
  • Emmanuel Ssemmondo,
  • Theodore D Ruel,
  • Florence Mwangwa,
  • Khai Hoan Tram,
  • Tamara D Clark,
  • Dalsone Kwarisiima,
  • Maya Petersen,
  • Moses R Kamya,
  • Edwin D Charlebois,
  • Diane V Havlir

DOI
https://doi.org/10.1371/journal.pone.0228102
Journal volume & issue
Vol. 15, no. 1
p. e0228102

Abstract

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BackgroundThe age-specific epidemiology of child and adolescent tuberculosis (TB) is poorly understood, especially in rural areas of East Africa. We sought to characterize the age-specific prevalence and predictors of TB infection among children and adolescents living in rural Uganda, and to explore the contribution of household TB exposure on TB infection.MethodsFrom 2015-2016 we placed and read 3,121 tuberculin skin tests (TST) in children (5-11 years old) and adolescents (12-19 years old) participating in a nested household survey in 9 rural Eastern Ugandan communities. TB infection was defined as a positive TST (induration ≥10mm or ≥5mm if living with HIV). Age-specific prevalence was estimated using inverse probability weighting to adjust for incomplete measurement. Generalized estimating equations were used to assess the association between TB infection and multi-level predictors.ResultsThe adjusted prevalence of TB infection was 8.5% (95%CI: 6.9-10.4) in children and 16.7% (95% CI:14.0-19.7) in adolescents. Nine percent of children and adolescents with a prevalent TB infection had a household TB contact. Among children, having a household TB contact was strongly associated with TB infection (aOR 5.5, 95% CI: 1.7-16.9), but the strength of this association declined among adolescents and did not meet significance (aOR 2.3, 95% CI: 0.8-7.0). The population attributable faction of TB infection due to a household TB contact was 8% for children and 4% among adolescents. Mobile children and adolescents who travel outside of their community for school had a 1.7 (95% CI 1.0-2.9) fold higher odds of TB infection than those who attended school in the community.ConclusionChildren and adolescents in this area of rural eastern Uganda suffer a significant burden of TB. The majority of TB infections are not explained by a known household TB contact. Our findings underscore the need for community-based TB prevention interventions, especially among mobile youth.