Nature Communications (Mar 2021)
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
- Tomoyuki Yoshida,
- Atsushi Yamagata,
- Ayako Imai,
- Juhyon Kim,
- Hironori Izumi,
- Shogo Nakashima,
- Tomoko Shiroshima,
- Asami Maeda,
- Shiho Iwasawa-Okamoto,
- Kenji Azechi,
- Fumina Osaka,
- Takashi Saitoh,
- Katsumi Maenaka,
- Takashi Shimada,
- Yuko Fukata,
- Masaki Fukata,
- Jumpei Matsumoto,
- Hisao Nishijo,
- Keizo Takao,
- Shinji Tanaka,
- Shigeo Okabe,
- Katsuhiko Tabuchi,
- Takeshi Uemura,
- Masayoshi Mishina,
- Hisashi Mori,
- Shuya Fukai
Affiliations
- Tomoyuki Yoshida
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Atsushi Yamagata
- RIKEN Center for Biosystems Dynamics Research
- Ayako Imai
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Juhyon Kim
- Division of Bio-Information Engineering, Faculty of Engineering, University of Toyama
- Hironori Izumi
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Shogo Nakashima
- Department of System Emotional Science, Faculty of Medicine, University of Toyama
- Tomoko Shiroshima
- Department of Anatomy, Kitasato University School of Medicine
- Asami Maeda
- Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine
- Shiho Iwasawa-Okamoto
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Kenji Azechi
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Fumina Osaka
- Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University
- Takashi Saitoh
- Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University
- Katsumi Maenaka
- Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University
- Takashi Shimada
- SHIMADZU Bioscience Research Partnership, Innovation Center, Shimadzu Scientific Instruments
- Yuko Fukata
- Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences
- Masaki Fukata
- Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences
- Jumpei Matsumoto
- Research Center for Idling Brain Science, University of Toyama
- Hisao Nishijo
- Research Center for Idling Brain Science, University of Toyama
- Keizo Takao
- Research Center for Idling Brain Science, University of Toyama
- Shinji Tanaka
- Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo
- Shigeo Okabe
- Department of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo
- Katsuhiko Tabuchi
- JST PRESTO
- Takeshi Uemura
- Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
- Masayoshi Mishina
- Brain Science Laboratory, Research Organization of Science and Technology, Ritsumeikan University
- Hisashi Mori
- Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama
- Shuya Fukai
- Department of Chemistry, Graduate School of Science, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-021-22059-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in development of social behaviour in mice.
