Nature Communications (Jan 2020)

Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes

  • Munira Taj Muhammad,
  • Yihang Jiao,
  • Changqing Ye,
  • Mong-Feng Chiou,
  • Muhammad Israr,
  • Xiaotao Zhu,
  • Yajun Li,
  • Zhenhai Wen,
  • Armido Studer,
  • Hongli Bao

DOI
https://doi.org/10.1038/s41467-019-14254-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

Fluorinated or fluoroalkylated allenes are versatile building blocks for medicinal and material chemistry. Here, the authors show a regioselective trifunctionalization of 1,3-enynes proceeding through double C-F bond formation and concomitant installation of a -NSO2Ph group to the allene moiety.