Preparation of implantable drug carrier-ordered porous HA/β-TCP composite

Abstract

HA/β-TCP composite with good biocompatibility and bioactivity had received attention in the field of implantable drug carrier. In order to improve its drug release performance, HA/β-TCP was prepared using low-temperature precipitation method by adjusting pH value and ordered porous morphology were designed and obtained using template method. Using IBU as the drug model, in vitro drug simulation release experiments were conducted on this material. With increase of pH value, the IBU-loading capacity of this composite gradually decreased, and at a pH value of 6, the IBU-loading capacity could reach 101.3mg/g. The in vitro simulated IBU release experiment indicated that during the rapid release stage of IBU, the ordered porous composite improved sudden drug release phenomenon to varying degrees and all the composites showed good slow-release performance. The composite obtained at a pH of 6 exhibited the best release of IBU, with a cumulative release rate of 86.35%.

Keywords

• implantable drug carrier
• biphasic calcium phosphate
• low-temperature
• ordered porous