Nature Communications (Dec 2017)

HEB is required for the specification of fetal IL-17-producing γδ T cells

  • Tracy S. H. In,
  • Ashton Trotman-Grant,
  • Shawn Fahl,
  • Edward L. Y. Chen,
  • Payam Zarin,
  • Amanda J. Moore,
  • David L. Wiest,
  • Juan Carlos Zúñiga-Pflücker,
  • Michele K. Anderson

DOI
https://doi.org/10.1038/s41467-017-02225-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The γδ T cell pool includes abundant IL-17-producing cells that protect mucosal surfaces, but the signals that control γδ T cell specification are unclear. Here the authors identify a role for the transcription factor HEB, and antagonistic activity of Id3, in the development of these cells.