Multicomponent double Mannich alkylamination involving C(sp2)–H and benzylic C(sp3)–H bonds

Zhencheng Lai; Rongkai Wu; Jiaming Li; Xing Chen; Linwei Zeng; Xi Wang; Jingjing Guo; Zujin Zhao; Hironao Sajiki; Sunliang Cui

doi:10.1038/s41467-022-28088-z

Nature Communications (Jan 2022)

Multicomponent double Mannich alkylamination involving C(sp2)–H and benzylic C(sp3)–H bonds

Zhencheng Lai,
Rongkai Wu,
Jiaming Li,
Xing Chen,
Linwei Zeng,
Xi Wang,
Jingjing Guo,
Zujin Zhao,
Hironao Sajiki,
Sunliang Cui

Affiliations

Zhencheng Lai: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University
Rongkai Wu: Department of Chemistry, Zhejiang University
Jiaming Li: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University
Xing Chen: Institute of Molecular Plus, Tianjin University
Linwei Zeng: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University
Xi Wang: School of Science, Beijing Jiaotong University
Jingjing Guo: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology
Zujin Zhao: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology
Hironao Sajiki: Laboratory of Organic Chemistry, Gifu-Pharmaceutical University
Sunliang Cui: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University

DOI: https://doi.org/10.1038/s41467-022-28088-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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The Mannich reaction is a three-component reaction for preparing alkylamines, but the nucleophilic components rely on C(sp2)−H and activated C(sp3)−H bonds. Here, the authors report an unprecedented multicomponent double Mannich alkylamination for both C(sp2)−H and unactivated benzylic C(sp3)−H bonds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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