Nature Communications (Sep 2019)
Caspase-11 signaling enhances graft-versus-host disease
- Yanyan Lu,
- Ran Meng,
- Xiangyu Wang,
- Yajing Xu,
- Yiting Tang,
- Jianfeng Wu,
- Qianqian Xue,
- Songlin Yu,
- Mingwu Duan,
- Dongyong Shan,
- Qingde Wang,
- Haichao Wang,
- Timothy R. Billiar,
- Xianzhong Xiao,
- Fangping Chen,
- Ben Lu
Affiliations
- Yanyan Lu
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Ran Meng
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Xiangyu Wang
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Yajing Xu
- Department of Hematology, Xiangya Hospital, Central South University
- Yiting Tang
- Department of Physiology, School of Basic Medical Science, Central South University
- Jianfeng Wu
- State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences, Xiamen University
- Qianqian Xue
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Songlin Yu
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Mingwu Duan
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Dongyong Shan
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Qingde Wang
- Department of Surgery, University of Pittsburgh Medical Center
- Haichao Wang
- The Feinstein Institute for Medical Research, Northwell Health
- Timothy R. Billiar
- Department of Surgery, University of Pittsburgh Medical Center
- Xianzhong Xiao
- Key Laboratory of Sepsis Translational Medicine of Hunan, Central South University
- Fangping Chen
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- Ben Lu
- Department of Hematology and Critical Care Medicine, The 3rd Xiangya Hospital, Central South University
- DOI
- https://doi.org/10.1038/s41467-019-11895-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.
