Effect of Process Parameters on the critical attributes of the Liposomal formulations

Abstract

This study investigate the effect of process parameters on the size, distribution, zeta potential and loading efficiency for the co-delivery of liposomal formulation of Ran-RCC1 inhibitory peptide (RANIP) and doxorubicin (DOX) to breast cancer. The results show that drug concentration, pH and ultrasound intensity are all critical factors to control the attributes of the liposomes.

Keywords

• liposomes
• drug-delivery
• formulations
• stability