Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: enhancing gut probiotics abundance and the tryptophan-melatonin pathway
Yiting Liu,
Longjie Li,
Jing Feng,
Bing Wan,
Qiang Tu,
Wei Cai,
Fa Jin,
Guiying Tang,
Lígia R. Rodrigues,
Xiuwei Zhang,
Jia Yin,
Yunlei Zhang
Affiliations
Yiting Liu
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Longjie Li
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Jing Feng
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Bing Wan
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Qiang Tu
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Wei Cai
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Fa Jin
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Guiying Tang
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Lígia R. Rodrigues
CEB - Centre of Biological Engineering, University of Minho, Braga, Portugal
Xiuwei Zhang
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
Jia Yin
Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, College of Life Sciences, Hunan Normal University, Changsha, China
Yunlei Zhang
Department of Respiratory and Critical Care Medicine, Central Laboratory, Translational Medicine Research Center, Department of Pathology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, P. R. China
ABSTRACTChronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between the dysbiosis of gut microbiota and COPD, and their metabolites have emerged as potential modulators of disease progression through the intricate gut-lung axis. Here, we demonstrate the efficacy of oral administration of the probiotic Pediococcus pentosaceus SMM914 (SMM914) in delaying the progression of COPD by attenuating pulmonary oxidative stress. Specially, SMM914 induces a notable shift in the gut microbiota toward a community structure characterized by an augmented abundance of probiotics producing short-chain fatty acids and antioxidant metabolisms. Concurrently, SMM914 synthesizes L-tryptophanamide, 5-hydroxy-L-tryptophan, and 3-sulfino-L-alanine, thereby enhancing the tryptophan-melatonin pathway and elevating 6-hydroxymelatonin and hypotaurine in the lung environment. This modulation amplifies the secretion of endogenous anti-inflammatory factors, diminishes macrophage polarization toward the M1 phenotype, and ultimately mitigates the oxidative stress in mice with COPD. The demonstrated efficacy of the probiotic intervention, specifically with SMM914, not only highlights the modulation of intestine microbiota but also emphasizes the consequential impact on the intricate interplay between the gastrointestinal system and respiratory health.
