Nature Communications (Feb 2020)
MYCN amplification and ATRX mutations are incompatible in neuroblastoma
- Maged Zeineldin,
- Sara Federico,
- Xiang Chen,
- Yiping Fan,
- Beisi Xu,
- Elizabeth Stewart,
- Xin Zhou,
- Jongrye Jeon,
- Lyra Griffiths,
- Rosa Nguyen,
- Jackie Norrie,
- John Easton,
- Heather Mulder,
- Donald Yergeau,
- Yanling Liu,
- Jianrong Wu,
- Collin Van Ryn,
- Arlene Naranjo,
- Michael D. Hogarty,
- Marcin M. Kamiński,
- Marc Valentine,
- Shondra M. Pruett-Miller,
- Alberto Pappo,
- Jinghui Zhang,
- Michael R. Clay,
- Armita Bahrami,
- Peter Vogel,
- Seungjae Lee,
- Anang Shelat,
- Jay F. Sarthy,
- Michael P. Meers,
- Rani E. George,
- Elaine R. Mardis,
- Richard K. Wilson,
- Steven Henikoff,
- James R. Downing,
- Michael A. Dyer
Affiliations
- Maged Zeineldin
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Sara Federico
- Department of Oncology, St. Jude Children’s Research Hospital
- Xiang Chen
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Yiping Fan
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Beisi Xu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Elizabeth Stewart
- Department of Oncology, St. Jude Children’s Research Hospital
- Xin Zhou
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jongrye Jeon
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Lyra Griffiths
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Rosa Nguyen
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Jackie Norrie
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- John Easton
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Heather Mulder
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Donald Yergeau
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Yanling Liu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jianrong Wu
- Department of Biostatistics, St. Jude Children’s Research Hospital
- Collin Van Ryn
- Children’s Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida
- Arlene Naranjo
- Children’s Oncology Group Statistics and Data Center, Department of Biostatistics, University of Florida
- Michael D. Hogarty
- Division of Oncology, Children’s Hospital of Philadelphia
- Marcin M. Kamiński
- Department of Immunology, St. Jude Children’s Research Hospital
- Marc Valentine
- Cytogenetics Shared Resource, St. Jude Children’s Research Hospital
- Shondra M. Pruett-Miller
- Center for Advanced Genome Engineering, St. Jude Children’s Research Hospital
- Alberto Pappo
- Department of Oncology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Michael R. Clay
- Department of Pathology, St. Jude Children’s Research Hospital
- Armita Bahrami
- Department of Pathology, St. Jude Children’s Research Hospital
- Peter Vogel
- Department of Pathology, St. Jude Children’s Research Hospital
- Seungjae Lee
- Department of Pathology, St. Jude Children’s Research Hospital
- Anang Shelat
- Department of Chemical Biology and Therapeutics St. Jude Children’s Research Hospital
- Jay F. Sarthy
- Basic Science Division, Fred Hutchinson Cancer Research Center
- Michael P. Meers
- Basic Science Division, Fred Hutchinson Cancer Research Center
- Rani E. George
- Department of Hematology/Oncology, Dana Farber Cancer Institute
- Elaine R. Mardis
- The Institute for Genomic Medicine, Nationwide Children’s Hospital
- Richard K. Wilson
- The Institute for Genomic Medicine, Nationwide Children’s Hospital
- Steven Henikoff
- Basic Science Division, Fred Hutchinson Cancer Research Center
- James R. Downing
- Department of Pathology, St. Jude Children’s Research Hospital
- Michael A. Dyer
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-020-14682-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
