SRC promotes lipogenesis: implications for obesity and breast cancer

Abstract

Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase Src interacts with and phosphorylates the lipogenesis enzyme phosphatidate phosphatase LPIN1 to promote breast cancer development.

Keywords

• lpin1
• src
• phosphatidylethanolamine
• lipogenesis
• breast cancer