Nature Communications (Apr 2020)

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

  • Yang Wu,
  • Ting Qi,
  • Huanwei Wang,
  • Futao Zhang,
  • Zhili Zheng,
  • Jennifer E. Phillips-Cremins,
  • Ian J. Deary,
  • Allan F. McRae,
  • Naomi R. Wray,
  • Jian Zeng,
  • Jian Yang

DOI
https://doi.org/10.1038/s41467-020-15587-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Promoter-anchored chromatin interaction (PAI) is a mechanism by which gene expression is regulated, but methods to measure PAIs are costly and currently not scalable. Here, the authors develop an approach by which PAIs can be predicted using summary-level data from methylation QTL studies.