Modulation of Nuclear Receptor Action and Regulation of Medicines Biotransformation

Abstract

Nuclear receptors are transcription factors that are essential in embryonic development, cellular differentiation, metabolism . Ligand-regulated nuclear PXR receptor responds to diverse arrays of chemically distinct ligands , xenobiotics, drugs and regulates expression of the genes involved in xenobiotic and drug metabolism. The structural basis of the receptor provides interaction with a variety of ligands which are agonists or antagonists. Nuclear receptors researches are important for design of metabolism regulating drugs and in drug interaction studies.

Keywords

• pxr рецептор
• cyp3a4 цитохром
• nuclear receptors
• pxr receptor
• xenobiotic biotransformation
• cyp3a4 cytochrome