Common neural dysfunction of economic decision-making across psychiatric conditions
Chunliang Feng,
Qingxia Liu,
Chuangbing Huang,
Ting Li,
Li Wang,
Feilong Liu,
Simon B. Eickhoff,
Chen Qu
Affiliations
Chunliang Feng
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China; Corresponding authors at: School of Psychology, South China Normal University, Guangzhou, China.
Qingxia Liu
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China
Chuangbing Huang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China
Ting Li
Institute of Brain and Psychological Science, Sichuan Normal University, Chengdu, 610066, China
Li Wang
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China
Feilong Liu
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China
Simon B. Eickhoff
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, 40225, Germany; Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, Jülich, 52428, Germany
Chen Qu
Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Guangzhou, 510631, China; School of Psychology, South China Normal University, Guangzhou, 510631, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, 510631, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, 510631, China; Corresponding authors at: School of Psychology, South China Normal University, Guangzhou, China.
Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis. Our findings indicate that there were transdiagnostic alterations in the thalamus and ventral striatum during the decision or outcome stage of decision-making. The identified regions represent key nodes in a large-scale network, which is composed of multiple heterogeneous brain regions and plays a causal role in motivational functioning. The findings suggest that disturbances in the network associated with emotion- and reward-related processing play a key role in dysfunctions of decision‐making observed in various psychiatric conditions. This study provides the first meta-analytic evidence of common neural alterations linked to deficits in economic decision-making.
