Nature Communications (Mar 2016)

A ligand-independent integrin β1 mechanosensory complex guides spindle orientation

  • Nicoletta I. Petridou,
  • Paris A. Skourides

DOI
https://doi.org/10.1038/ncomms10899
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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During cell division, the orientation of the mitotic spindle is sensitive to forces exerted on the cell cortex. Here Petridou and Skourides show that such cues are sensed by a mechanosensory complex established on force activated integrin β1 independent of ligand binding.