Quantitative assessment of TLR4 gene polymorphisms and T2DM risk: A meta‐analysis

Abstract

Abstract Background Numerous studies have evaluated the association between TLR4 gene polymorphisms and T2DM risk. However, the findings were inconsistent and controversial. Methods In order to drive a more precise estimation, we carried out a meta‐analysis based on 41 studies involving 23,250 cases and 24,760 controls. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. Results Our meta‐analysis provides evidence that rs4986790 polymorphism was associated with an increased risk of T2DM in Asian (AG vs. AA, OR = 1.23, 95% CI = 1.01–1.50, p = 0.042; G vs. A, OR = 1.21, 95% CI = 1.01–1.44, p = 0.041). Rs4986791 polymorphism was related to an increased risk of T2DM both in Asian (AG vs. AA, OR = 1.76, 95% CI = 1.11–2.80, p = 0.017; G vs. A, OR = 1.63, 95% CI = 1.04–2.55, p = 0.034) and Caucasian (GG vs. AA, OR = 2.42, 95% CI = 1.23–4.75, p = 0.010). Rs11536889 polymorphism may have a protective effect on T2DM in Chinese populations (CC vs. GG, OR = 0.62, 95% CI = 0.40–0.96, p = 0.031; GC vs. GG, OR = 0.77, 95% CI = 0.61–0.98, p = 0.034; CC vs. GC/GG, OR = 0.81, 95% CI = 0.69–0.96, p = 0.013; C vs. G, OR = 0.76, 95% CI = 0.59–0.97, p = 0.027), whereas rs1927911 may have no impact. Conclusions These findings supported that rs4986790, rs4986791, and rs11536889 may contribute to the risk of T2DM.

Keywords

• meta‐analysis
• polymorphism
• risk
• T2DM
• TLR4