Modern concepts of the role of platelet receptors in the dynamics of thrombus formation

Abstract

The study of molecular and biological aspects of the platelets functioning with the use of biochemical methods, new technologies of cell and molecular biology became the basis for understanding signaling cascades regulating the activation, adhesion and aggregation of these cells. In this review, the general modern information of the role of platelet membrane receptors in physiological and pathological processes of thrombus formation was performed. The possible role of platelet receptors as target of antiagregatory agents was analyzed. Also, new promising areas of searching for effective and specific antithrombotic agents were identified.

Keywords

• platelets, membrane receptors, the process of thrombosis, aggregation