Communications Biology (Dec 2022)
Dickkopf1 fuels inflammatory cytokine responses
- Nikolai P. Jaschke,
- Sophie Pählig,
- Anupam Sinha,
- Timon E. Adolph,
- Maria Ledesma Colunga,
- Maura Hofmann,
- Andrew Wang,
- Sylvia Thiele,
- Julian Schwärzler,
- Alexander Kleymann,
- Marc Gentzel,
- Herbert Tilg,
- Ben Wielockx,
- Lorenz C. Hofbauer,
- Martina Rauner,
- Andy Göbel,
- Tilman D. Rachner
Affiliations
- Nikolai P. Jaschke
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Sophie Pählig
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Anupam Sinha
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Timon E. Adolph
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, and Metabolism, Innsbruck Medical University
- Maria Ledesma Colunga
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Maura Hofmann
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Andrew Wang
- Department of Medicine (Rheumatology, Allergy & Immunology), Yale University School of Medicine
- Sylvia Thiele
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Julian Schwärzler
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, and Metabolism, Innsbruck Medical University
- Alexander Kleymann
- Division of Rheumatology, Department of Medicine III, Technische Universität Dresden
- Marc Gentzel
- Molecular Analysis - Mass Spectrometry, Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden
- Herbert Tilg
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, and Metabolism, Innsbruck Medical University
- Ben Wielockx
- Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden
- Lorenz C. Hofbauer
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Martina Rauner
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Andy Göbel
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- Tilman D. Rachner
- Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s42003-022-04368-8
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.
