A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

Jessyane Rodrigues do Nascimento; Amanda de Jesus Alves Miranda; Felipe Costa Vieira; Carla Daniele Pinheiro Rodrigues; Luna Nascimento Vasconcelos; José Lima Pereira Filho; Auxiliadora Cristina Corrêa Barata Lopes; Marcelo Marucci Pereira Tangerina; Wagner Vilegas; Cláudia Quintino da Rocha

doi:10.3390/ph15060658

Pharmaceuticals (May 2022)

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

Jessyane Rodrigues do Nascimento,
Amanda de Jesus Alves Miranda,
Felipe Costa Vieira,
Carla Daniele Pinheiro Rodrigues,
Luna Nascimento Vasconcelos,
José Lima Pereira Filho,
Auxiliadora Cristina Corrêa Barata Lopes,
Marcelo Marucci Pereira Tangerina,
Wagner Vilegas,
Cláudia Quintino da Rocha

Affiliations

Jessyane Rodrigues do Nascimento: Institut of Biosciences, Coastal Campus of São Vicente, Universidade Estadual Paulista-UNESP, São Vicente 11330-900, SP, Brazil
Amanda de Jesus Alves Miranda: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
Felipe Costa Vieira: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
Carla Daniele Pinheiro Rodrigues: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
Luna Nascimento Vasconcelos: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
José Lima Pereira Filho: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
Auxiliadora Cristina Corrêa Barata Lopes: Biodiversity and Biotechnology Graduate Program-BIONORTE, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil
Marcelo Marucci Pereira Tangerina: Botany Department, Institute of Biosciences, University of São Paulo-USP, São Paulo 05508-090, SP, Brazil
Wagner Vilegas: Institut of Biosciences, Coastal Campus of São Vicente, Universidade Estadual Paulista-UNESP, São Vicente 11330-900, SP, Brazil
Cláudia Quintino da Rocha: Department of Chemistry, Federal University of Maranhão-UFMA, São Luís 65080-805, MA, Brazil

DOI: https://doi.org/10.3390/ph15060658
Journal volume & issue: Vol. 15, no. 6
p. 658

Abstract

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The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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