Ir(III) Complexes with AIE Characteristics for Biological Applications
Yu Pei,
Yan Sun,
Meijia Huang,
Zhijun Zhang,
Dingyuan Yan,
Jie Cui,
Dongxia Zhu,
Zebing Zeng,
Dong Wang,
Benzhong Tang
Affiliations
Yu Pei
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Yan Sun
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Meijia Huang
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Zhijun Zhang
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Dingyuan Yan
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Jie Cui
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Dongxia Zhu
Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, China
Zebing Zeng
Shenzhen Research Institute of Hunan University, Shenzhen 518000, China
Dong Wang
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Benzhong Tang
Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Both biological process detection and disease diagnosis on the basis of luminescence technology can provide comprehensive insights into the mechanisms of life and disease pathogenesis and also accurately guide therapeutics. As a family of prominent luminescent materials, Ir(III) complexes with aggregation-induced emission (AIE) tendency have been recently explored at a tremendous pace for biological applications, by virtue of their various distinct advantages, such as great stability in biological media, excellent fluorescence properties and distinctive photosensitizing features. Significant breakthroughs of AIE-active Ir(III) complexes have been achieved in the past few years and great progress has been witnessed in the construction of novel AIE-active Ir(III) complexes and their applications in organelle-specific targeting imaging, multiphoton imaging, biomarker-responsive bioimaging, as well as theranostics. This review systematically summarizes the basic concepts, seminal studies, recent trends and perspectives in this area.
