Nature Communications (Jan 2018)
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss
- Sébastien Lucas,
- Yasunori Omata,
- Jörg Hofmann,
- Martin Böttcher,
- Aida Iljazovic,
- Kerstin Sarter,
- Olivia Albrecht,
- Oscar Schulz,
- Brenda Krishnacoumar,
- Gerhard Krönke,
- Martin Herrmann,
- Dimitrios Mougiakakos,
- Till Strowig,
- Georg Schett,
- Mario M. Zaiss
Affiliations
- Sébastien Lucas
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Yasunori Omata
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Jörg Hofmann
- Division of Biochemistry, Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg (FAU)
- Martin Böttcher
- Department of Internal Medicine 5, Hematology and Oncology, Translational Research Center, University Hospital Erlangen
- Aida Iljazovic
- Helmholtz Centre for Infection Research
- Kerstin Sarter
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Olivia Albrecht
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Oscar Schulz
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Brenda Krishnacoumar
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Gerhard Krönke
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Martin Herrmann
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Dimitrios Mougiakakos
- Department of Internal Medicine 5, Hematology and Oncology, Translational Research Center, University Hospital Erlangen
- Till Strowig
- Helmholtz Centre for Infection Research
- Georg Schett
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- Mario M. Zaiss
- Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen
- DOI
- https://doi.org/10.1038/s41467-017-02490-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Short-chain fatty acids (SCFA) are a main class of metabolites derived from fermentation of dietary fibre in the intestine. Here, the authors show that dietary administration of SCFA is associated with inhibition of osteoclast differentiation, increased bone mass, and reduced pathological bone loss in mice.
