A gene regulatory network to control EMT programs in development and disease

Hassan Fazilaty; Luciano Rago; Khalil Kass Youssef; Oscar H. Ocaña; Francisco Garcia-Asencio; Aida Arcas; Juan Galceran; M. Angela Nieto

doi:10.1038/s41467-019-13091-8

Nature Communications (Nov 2019)

A gene regulatory network to control EMT programs in development and disease

Hassan Fazilaty,
Luciano Rago,
Khalil Kass Youssef,
Oscar H. Ocaña,
Francisco Garcia-Asencio,
Aida Arcas,
Juan Galceran,
M. Angela Nieto

Affiliations

Hassan Fazilaty: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Luciano Rago: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Khalil Kass Youssef: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Oscar H. Ocaña: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Francisco Garcia-Asencio: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Aida Arcas: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
Juan Galceran: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’
M. Angela Nieto: Instituto de Neurociencias (CSIC-UMH), Avda. Ramón y Cajal s/n, Sant Joan d’

DOI: https://doi.org/10.1038/s41467-019-13091-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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