Functional State of Pituitary-Gonadal System in Men with Non-functional Pituitary Adenomas and Growth Hormone Deficiency in Adults

Abstract

We examined 71 adult patients with growth hormone deficiency caused by non-functional masses of chiasmosellar area. Patients were divided into two groups: the first one — men aged 18 to 49 years and the second one — 49 years and above. Investigation of the hormonal profile of the first group patients showed that in them low indices of the mean values of luteinizing hormone (LH), follicle-stimulating hormone (FSH), free and total testosterone (hypogonadotropic hypogonadism) dominated on the background of moderate hyperprolactinemia. In the patients of the second group we found similar violations of the pituitary-gonadal axis. In patients of older age group the low indices of the mean values of LH, FSH, total testosterone (hypogonadotropic hypogonadism) also dominated on the background of moderate hyperprolactinemia. At that, the average values of these hormones were significantly lower than in the first group.