A VEGFR targeting peptide-drug conjugate (PDC) suppresses tumor angiogenesis in a TACE model for hepatocellular carcinoma therapy

Dongyuan Wang; Jiacheng Liu; Tongqiang Li; Yingliang Wang; Xiaoming Liu; Yaowei Bai; Chaoyang Wang; Shuguang Ju; Songjiang Huang; Chongtu Yang; Chen Zhou; Yu Zhang; Bin Xiong

doi:10.1038/s41420-022-01198-9

Cell Death Discovery (Oct 2022)

A VEGFR targeting peptide-drug conjugate (PDC) suppresses tumor angiogenesis in a TACE model for hepatocellular carcinoma therapy

Dongyuan Wang,
Jiacheng Liu,
Tongqiang Li,
Yingliang Wang,
Xiaoming Liu,
Yaowei Bai,
Chaoyang Wang,
Shuguang Ju,
Songjiang Huang,
Chongtu Yang,
Chen Zhou,
Yu Zhang,
Bin Xiong

Affiliations

Dongyuan Wang: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Jiacheng Liu: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tongqiang Li: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yingliang Wang: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xiaoming Liu: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yaowei Bai: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chaoyang Wang: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Shuguang Ju: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Songjiang Huang: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chongtu Yang: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chen Zhou: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yu Zhang: Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Bin Xiong: Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41420-022-01198-9
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

Schematic presentation of the design of VEGFR targeting peptide conjugate (QR-KLU) and the antineoplastic efficacy of peptide QR-KLU in vitro and in vivo.

Published in Cell Death Discovery

ISSN: 2058-7716 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: http://www.nature.com/cddiscovery/

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