Value biomarker diagnosis and prediction of acute renal damage in patients with acute coronary syndromes without ST-segment elevation

Abstract

Aim: to study the prognostic value of biomarkers (urine neutrophil gelatinase-associated lipocalin (uNGAL), urine interleukin-18 (uIL-18), serum cystatin C (sCysC), serum N-terminal prohormone of brain natriuretic peptide (sNT-proBNP) depending on the acute kidney injury (AKI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). 58 patients with NSTE-ACS were examined. Patients with NSTE-ACS and early AKI had higher sCysC, sNT-proBNP, uNGAL and uIL-18 levels than the patients without AKI. No relationship between biomarkers and in-hospital mortality was revealed in patients with cardiorenal syndrome (CRS). AKI — acute kidney injury NSTE-ACS — non-ST-elevation acute coronary syndrome CRS — cardiorenal syndrome NT-proBNP — N-terminal prohormone of Brain Natriuretic Peptide IL-18 — interleukin-18 NGAL — neutrophil gelatinase-associated lipocalin

Keywords

• острый коронарный синдром без подъема сегмента ST
• острое почечное повреждение
• кардиоренальный синдром
• терминальный фрагмент предшественника мозгового натрийуретического пептида в сыворотке крови
• интерлейкин-18
• липокалин ассоциированный с желатиназой нейтрофилов