Beilstein Journal of Organic Chemistry (Aug 2012)
Organocatalytic asymmetric allylic amination of Morita–Baylis–Hillman carbonates of isatins
Abstract
The investigation of a Lewis base catalyzed asymmetric allylic amination of Morita–Baylis–Hillman carbonates derived from isatins afforded an electrophilic pathway to access multifunctional oxindoles bearing a C3-quaternary stereocenter, provided with good to excellent enantioselectivity (up to 94% ee) and in high yields (up to 97%).
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