Nature Communications (Aug 2021)

Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts

  • Deukchae Na,
  • Jeesoo Chae,
  • Sung-Yup Cho,
  • Wonyoung Kang,
  • Ahra Lee,
  • Seoyeon Min,
  • Jinjoo Kang,
  • Min Jung Kim,
  • Jaeyong Choi,
  • Woochan Lee,
  • Dongjin Shin,
  • Ahrum Min,
  • Yu-Jin Kim,
  • Kyung-Hun Lee,
  • Tae-Yong Kim,
  • Yun-Suhk Suh,
  • Seong-Ho Kong,
  • Hyuk-Joon Lee,
  • Woo-Ho Kim,
  • Hansoo Park,
  • Seock-Ah Im,
  • Han-Kwang Yang,
  • Charles Lee,
  • Jong-Il Kim

DOI
https://doi.org/10.1038/s41467-021-25122-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorouracil and oxaliplatin-based chemotherapy through the integrative profiling of patient-derived xenografts