AKTIVITAS ANALGETIK EKSTRAK ETANOL DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN

Abstract

Leaf melinjo (Gnetum gnemon L.) contain flavonoids that has the potential to reduce pain by blocking the action of the enzyme cyclooxygenase. This research was aims to determine the effect of ethanol extract of leaf melinjo of the analgesic effect in mice. Twenty-five mice were divided into 5 groups: negative control (CMC Na 0,5%), positive control group (mefenamic acid 1.3 mg / kg) and groups melinjo leaf extract (dose of 6.48 mg / kg, 25.92 mg / kg and 51.84 mg / BB) on white male mice. Analgesic test were examined by giving pain stimulation to treated animals, such a 55°C heat stimulation. The observation, then at 30, 60, 90 and 120 minutes after administered.The results showed melinjo leaf ethanol extract with a dose of 51.84 mg / kg have analgesic effects is no different significantly with mefenamic acid dose of 1.3 mg / kg body weight (P> 0.05).

Keywords

• Analgesic
• Anti-inflammatory
• Leaf melinjo