Nature Communications (Jun 2022)
Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales
- Kalisvar Marimuthu,
- Indumathi Venkatachalam,
- Vanessa Koh,
- Stephan Harbarth,
- Eli Perencevich,
- Benjamin Pei Zhi Cherng,
- Raymond Kok Choon Fong,
- Surinder Kaur Pada,
- Say Tat Ooi,
- Nares Smitasin,
- Koh Cheng Thoon,
- Paul Anantharajah Tambyah,
- Li Yang Hsu,
- Tse Hsien Koh,
- Partha Pratim De,
- Thean Yen Tan,
- Douglas Chan,
- Rama Narayana Deepak,
- Nancy Wen Sim Tee,
- Andrea Kwa,
- Yiying Cai,
- Yik-Ying Teo,
- Natascha May Thevasagayam,
- Sai Rama Sridatta Prakki,
- Weizhen Xu,
- Wei Xin Khong,
- David Henderson,
- Nicole Stoesser,
- David W. Eyre,
- Derrick Crook,
- Michelle Ang,
- Raymond Tzer Pin Lin,
- Angela Chow,
- Alex R. Cook,
- Jeanette Teo,
- Oon Tek Ng,
- Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group
Affiliations
- Kalisvar Marimuthu
- National Centre for Infectious Diseases
- Indumathi Venkatachalam
- Singapore General Hospital
- Vanessa Koh
- National Centre for Infectious Diseases
- Stephan Harbarth
- Infection Control Program, WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine
- Eli Perencevich
- Departments of Internal Medicine and Epidemiology, University of Iowa Carver College of Medicine
- Benjamin Pei Zhi Cherng
- Yong Loo Lin School of Medicine, National University of Singapore and National University Health System
- Raymond Kok Choon Fong
- Changi General Hospital
- Surinder Kaur Pada
- Ng Teng Fong General Hospital
- Say Tat Ooi
- Khoo Teck Puat Hospital
- Nares Smitasin
- Yong Loo Lin School of Medicine, National University of Singapore and National University Health System
- Koh Cheng Thoon
- KK Women’s and Children’s Hospital
- Paul Anantharajah Tambyah
- National University Hospital and National University Health System
- Li Yang Hsu
- Yong Loo Lin School of Medicine, National University of Singapore and National University Health System
- Tse Hsien Koh
- Singapore General Hospital
- Partha Pratim De
- Tan Tock Seng Hospital
- Thean Yen Tan
- Changi General Hospital
- Douglas Chan
- Ng Teng Fong General Hospital
- Rama Narayana Deepak
- Khoo Teck Puat Hospital
- Nancy Wen Sim Tee
- National University Hospital and National University Health System
- Andrea Kwa
- Singapore General Hospital
- Yiying Cai
- Singapore General Hospital
- Yik-Ying Teo
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Natascha May Thevasagayam
- National Centre for Infectious Diseases
- Sai Rama Sridatta Prakki
- National Centre for Infectious Diseases
- Weizhen Xu
- National Centre for Infectious Diseases
- Wei Xin Khong
- Tan Tock Seng Hospital
- David Henderson
- Clinical Centre, National Institutes of Health
- Nicole Stoesser
- Nuffield Department of Medicine, University of Oxford
- David W. Eyre
- Nuffield Department of Population Health, University of Oxford
- Derrick Crook
- Nuffield Department of Medicine, University of Oxford
- Michelle Ang
- National Centre for Infectious Diseases
- Raymond Tzer Pin Lin
- National Centre for Infectious Diseases
- Angela Chow
- Tan Tock Seng Hospital
- Alex R. Cook
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Jeanette Teo
- National University Hospital and National University Health System
- Oon Tek Ng
- National Centre for Infectious Diseases
- Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group
- DOI
- https://doi.org/10.1038/s41467-022-30637-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Carbapenemase-producing Enterobacterales cause healthcare-associated infections but modes of transmission are not well understood. Here, the authors find evidence of transmission without direct patient contact, indicating presence of undetected environmental reservoirs, whilst half of the transmission events are likely due to plasmid-mediated transmission.
