Frontiers in Public Health (Feb 2021)

Economic Value of Lost Productivity Attributable to Human Papillomavirus Cancer Mortality in the United States

  • Masoom Priyadarshini,
  • Vimalanand S. Prabhu,
  • Sonya J. Snedecor,
  • Shelby Corman,
  • Barbara J. Kuter,
  • Chizoba Nwankwo,
  • Diana Chirovsky,
  • Evan Myers

DOI
https://doi.org/10.3389/fpubh.2020.624092
Journal volume & issue
Vol. 8

Abstract

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Objectives: To estimate years of potential life lost (YPLL) and present value of future lost productivity (PVFLP) associated with premature mortality due to HPV-attributable cancers, specifically those targeted by nonavalent HPV (9vHPV) vaccination, in the United States (US) before vaccine use.Methods: YPLL was estimated from the reported number of deaths in 2017 due to HPV-related cancers, the proportion attributable to 9vHPV-targeted types, and age- and sex-specific US life expectancy. PVFLP was estimated as the product of YPLL by age- and sex-specific probability of labor force participation, annual wage, value of non-market labor, and fringe benefits markup factor.Results: An estimated 7,085 HPV-attributable cancer deaths occurred in 2017 accounting for 154,954 YPLL, with 6,482 deaths (91%) and 141,019 YPLL (91%) attributable to 9vHPV-targeted types. The estimated PVFLP was $3.8 billion for cancer deaths attributable to 9vHPV-targeted types (84% from women). The highest productivity burden was associated with cervical cancer in women and anal and oropharyngeal cancers in men.Conclusions: HPV-attributable cancer deaths are associated with a substantial economic burden in the US, much of which could be vaccine preventable.

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