EVALUATION THE SEDATIVE AND ANALGESICEFFECTFOR MIXTURE OF TRAMADOL AND METOCLOPRAMIDE IN SHEEP

Abstract

The aim of study was to explore the analgesic and sedative effects of tramadoland metoclopramide co-adminstration in sheep. Injection of tramadol intramuscular at5mg/kg body weight in sheep produced deep sedation, recompense and analgesia incomparison with dose of 2.5mg/kg body weight which produced only mild sedationand failed as analgesic dose. Intramuscular injection of metoclopramide at 20mg/kgbody weight in sheep produced deep sedation, recompense and analgesia incomparisons with dose of 10 mg/kg which produced only sedation and failed asanalgesic dose. Intramuscular injection of metoclopramide at dose20mg/kg ortramadol at 5mg/kg body weight in sheep each alone were produced deep sedation,recumbence and analgesia while metoclopramide at 10mg/kg body weight or tramadola(t2.5mg/kg b. W) produced only mild sedation and each dose felid to producedanalgesia in sheep. Concomitant administration of tramadol at dose2.5mg/kg bodyweight to sheep and metoclopramide at dose 10mg/kg body weight intramuscular assedatives not analgesia dose produced a significant increase in sedation score andproduced deep sedation with recompense as well as good analgesia in comparisonwith control group and group of tramadol or metoclopramide alone.

Keywords

• tramadol
• metoclopramide
• analgesia